Cabin1 expression suggests roles in neuronal development. Dev Dyn 2010 Sep;239(9):2443-51
Date
07/24/2010Pubmed ID
20652955DOI
10.1002/dvdy.22367Scopus ID
2-s2.0-77956272139 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Nervous system assembly and function depends on precise regulation of developmental gene expression. Cabin1, an essential gene in developing mice, is enriched in regions of the developing zebrafish central nervous system (CNS). Cabin1 is a repressor of MEF2- (myocyte enhancer factor 2) and calcineurin-mediated transcription in the immune system, but its function in the CNS during development is unknown. We identified Cabin1 from a library of genes enriched in developing neurons and determined the temporal and spatial expression of Cabin1 mRNA during CNS development. We found Cabin1 mRNA expression in the developing brain at times correlated with later aspects of neuronal differentiation. In some regions of the CNS Cabin1 expression overlaps with regions that also express proteins known to interact with Cabin1: MEF2 and/or calcineurin. We suggest that Cabin1 could act as a regulator of MEF2 and calcineurin activity in the developing nervous system, given their roles in neuronal differentiation and synaptic refinement.
Author List
Hammond DR, Udvadia AJAuthor
Ava Udvadia BS,PhD Associate Professor in the Biological Sciences department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
Adaptor Proteins, Signal TransducingAmino Acid Sequence
Animals
Calcineurin
Central Nervous System
Gene Expression Regulation, Developmental
Humans
Intracellular Signaling Peptides and Proteins
MEF2 Transcription Factors
Mice
Molecular Sequence Data
Myogenic Regulatory Factors
Neurons
Phosphoproteins
Phylogeny
Repressor Proteins
Sequence Alignment
Tissue Distribution
Zebrafish
Zebrafish Proteins
