Faculty Collaboration Database

Severe autoimmune neutropenia associated with acute autoimmune hepatitis. Int J Hematol 2010 May;91(4):673-8

Date

04/03/2010

Pubmed ID

20361278

DOI

10.1007/s12185-010-0557-1

Scopus ID

2-s2.0-77954540092 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm(3)), normal hemoglobin and mild thrombocytopenia (115000/mm(3)). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.

Author List

Wehbe AM, Johannsson B, Raife TJ, Bleile M, Bell A, Curtis BR, Halfdanarson TR

Author

Brian Curtis PhD Director in the Platelet & Neutrophil Immunology Laboratory department at BloodCenter of Wisconsin

MESH terms used to index this publication - Major topics in bold

Autoantibodies
Biopsy
Female
Hepatitis, Autoimmune
Humans
Leukocyte Count
Liver
Middle Aged
Neutropenia
Severity of Illness Index