A method for analysis of pulmonary arterial and venous occlusion data. J Appl Physiol (1985) 1992 Sep;73(3):1190-5
Date
09/01/1992Pubmed ID
1400035DOI
10.1152/jappl.1992.73.3.1190Scopus ID
2-s2.0-0026783832 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Recently, we presented a compartmental model of the pulmonary vascular resistance (R) and compliance (C) distribution with the configuration C1R1C2R2C3 (J. Appl. Physiol. 70: 2126-2136, 1991). This model was used to interpret the pressure vs. time data obtained after the sudden occlusion of the arterial inflow (AO), venous outflow (VO), or both inflow and outflow (DO) from an isolated dog lung lobe. In the present study, we present a new approach to the data analysis in terms of this model that is relatively simple to carry out and more robust. The data used to estimate the R's and C's are the steady-state arterial [Pa(0)] and venous [Pv(0)] pressures, the flow rate (Q), the area (A2) encompassed by Pa(t) after AO and the equilibrium pressure (Pd) after DO, and the average slope (m) of the Pa(t) and Pv(t) curves after VO. The following formulas can then be used to calculate the 2 R's and 3 C's: [Pa(0) - Pv(0)]/Q = R1 + R2 = RT, R1C1 congruent to to A2/[Pa(0) - Pd], R1 congruent to [Pa(0) - Pd]/Q, Q/m = C1 + C2 + C3 = CT, and C2 = CT - (RTC1/R2).
Author List
Audi SH, Dawson CA, Linehan JHAuthor
Said Audi PhD Professor in the Biomedical Engineering department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnimalsArteries
Constriction
Dogs
Evaluation Studies as Topic
In Vitro Techniques
Models, Cardiovascular
Pulmonary Circulation
Vascular Resistance
Veins