Movement of methylphenazyl free radicals in polar and nonpolar liquids. Free Radic Biol Med 1992;13(1):35-40
Date
01/01/1992Pubmed ID
1628851DOI
10.1016/0891-5849(92)90163-bScopus ID
2-s2.0-13344270408 (requires institutional sign-in at Scopus site)Abstract
A protonated, charged free radical of methylphenazine methosulfate (PMS) was generated at carbon electrodes in a buffered aqueous medium. This radical diffused from the aqueous phase into nonpolar organic solvents, where it was stable for extended periods. The electron spin resonance (ESR) spectrum of the free radical species in the nonpolar solvent was significantly different from that of the aqueous species. This difference was attributed to the loss of electric charge through deprotonation at the solution interface, followed by solvation of the uncharged species in the organic phase. ESR spectra are presented for PMS free radicals in polar and nonpolar liquid phases, along with electrochemical results and conclusions regarding the mechanisms of movement and toxicity of phenazyl free radicals in biological systems.
Author List
Catallo WJ, Feix JB, Gale RJAuthor
Jimmy B. Feix PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ElectrochemistryFree Radicals
Methylphenazonium Methosulfate
Solvents
Water