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Action spectra of the antileukemic and antiviral activities of merocyanine 540. Photochem Photobiol 1991 Nov;54(5):851-4

Date

11/01/1991

Pubmed ID

1665914

DOI

10.1111/j.1751-1097.1991.tb02101.x

Scopus ID

2-s2.0-0026251576 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

Action spectra of the antileukemic and antiviral activities of merocyanine 540 (MC540) were determined using L1210 leukemia cells and human Herpes simplex virus type 1. The major peak of both action spectra aligned closely with the absorption spectrum of membrane-bound dye monomer, and by implication, the action spectrum of 1O2 generation. These results are compatible with the notion that the antileukemic and antiviral activities of MC540 are primarily attributable to membrane-bound monomer and at least in part mediated by 1O2.

Author List

O'Brien JM, Singh RJ, Feix JB, Kalyanaraman B, Sieber F

Authors

Jimmy B. Feix PhD Professor in the Biophysics department at Medical College of Wisconsin
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin
Fritz Sieber PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Fluorescent Dyes
Herpes Simplex
Humans
Leukemia
Membranes
Mice
Pyrimidinones
Simplexvirus
Spectrophotometry
Tumor Cells, Cultured