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Eight-point glucose testing versus the continuous glucose monitoring system in evaluation of glycemic control in type 1 diabetes. J Clin Endocrinol Metab 2005 Jun;90(6):3387-91



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Scopus ID

2-s2.0-21244434882 (requires institutional sign-in at Scopus site)   81 Citations


CONTEXT: Advantages/disadvantages of continuous vs. discrete glucose monitoring are not well documented.

OBJECTIVE: Compare glucose profiles from home meters vs. continuous sensors.

DESIGN: Randomized clinical trial conducted by the Diabetes Research in Children Network (DirecNet) to assess the utility of the GlucoWatch G2 Biographer.

SETTING: Home glucose measurements.

PATIENTS: Two hundred children (age, 7 to < 18 yr) with type 1 diabetes.

INTERVENTION: At baseline, subjects were asked to wear the continuous glucose monitoring system (CGMS) sensor and perform meter tests at eight prespecified times of the day (eight-point testing) each for 3 d (2 d using both, 1 d eight-point testing only, 1 d CGMS only). Hemoglobin A1c was measured in a central laboratory.

MAIN OUTCOME MEASURE: Six-month hemoglobin A1c. This analysis looked at baseline glucose profiles/hemoglobin A1c.

RESULTS: Only 10% of subjects completed full eight-point testing for 3 d, but median CGMS use was 70 h. Mean glucose was lower when measured by the CGMS compared with eight-point testing (183 +/- 37 vs. 188 +/- 41 mg/dl; 10.2 +/- 2.1 vs.10.4 +/- 2.3 mmol/liter; P = 0.009), especially overnight (2400-0400 h; 174 vs. 199 mg/dl; 9.7 vs. 11.1 mmol/liter; P < 0.001). Associations of hemoglobin A1c with mean glucose were similar for eight-point testing [slope 23 mg/dl per 1% (1.3 mmol/liter); correlation 0.40; P < 0.001] and CGMS [slope 19 mg/dl per 1% (1.1 mmol/liter); correlation 0.39; P < 0.001]. Postprandial excursions were lower for eight-point testing vs. CGMS, especially after dinner (mean excursion -17 vs. 63 mg/dl; -1.0 vs. 3.5 mmol/liter; P < 0.001).

CONCLUSIONS: Both methods gave similar mean glucose profiles and associations with hemoglobin A1c. Advantages of the CGMS were higher density of data and better detection of postprandial peaks. However, the CGMS may overestimate the frequency of low glucose levels, especially overnight.

Author List

Fiallo-Scharer R, Diabetes Research in Children Network Study Group


Rosanna V. Fiallo-Scharer MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Biosensing Techniques
Blood Glucose
Blood Glucose Self-Monitoring
Diabetes Mellitus, Type 1
Monitoring, Ambulatory
Monitoring, Physiologic
Patient Selection
Reproducibility of Results