Faculty Collaboration Database

Transpupillary thermotherapy of occult choroidal neovascularization in age-related macular degeneration. Semin Ophthalmol 2001 Jun;16(2):86-9

Date

10/20/2004

Pubmed ID

15491009

DOI

10.1076/soph.16.2.86.4212

Scopus ID

2-s2.0-0035735036 (requires institutional sign-in at Scopus site)   17 Citations

Abstract

PURPOSE: To evaluate the efficacy of transpupillary thermotherapy (TTT) in management of occult subfoveal choroidal neovascularization (CNV) in exudative age-related macular degeneration (AMD).

METHODS: Retrospective chart review of eyes that were treated with TTT and had at least 12 weeks of follow-up. Base-line and final ETDRS visual acuity and fluorescein angiography (FA) were compared.

RESULTS: For the 48 eyes which met inclusion criteria, mean pre-operative visual acuity was 20/128 (range: 20/50-20/500). Average follow-up was 27 weeks (range: 12 weeks-55 weeks). At 3 months after treatment, 12 eyes (25%) improved 2 lines or more, 18 eyes (37.5%) had no change or 1 line of visual improvement, and 18 eyes (37.5%) worsened 1 or more lines. No significant adverse event was noted during treatment. Three eyes developed large submacular hemorrhage within 2 months of treatment. Based on clinical examination and FA, 61% of the eyes appeared to have reduction of subretinal fluid compared to pre-operative evaluations.

CONCLUSION: Visual acuity was stable or improved in 62.5% of eyes in our series and the treatment was well tolerated. Longer follow up and larger number of patients would be required to evaluate the ultimate benefit of TTT in management of occult CNV due to AMD.

Author List

Kim JE, Perkins SL, Schwiesow T, Connor TB Jr, Han DP

Author

Thomas B. Connor MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Choroidal Neovascularization
Exudates and Transudates
Female
Fluorescein Angiography
Humans
Hyperthermia, Induced
Macular Degeneration
Male
Middle Aged
Postoperative Complications
Pupil
Retrospective Studies
Treatment Outcome
Visual Acuity