Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med 2014 Jan 01;189(1):96-103
Date
09/17/2013Pubmed ID
24033344Pubmed Central ID
PMC3919126DOI
10.1164/rccm.201306-1164WSScopus ID
2-s2.0-84891868645 (requires institutional sign-in at Scopus site) 56 CitationsAbstract
Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.
Author List
Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan WAuthor
Ivor J. Benjamin MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingBiomedical Research
Drug Discovery
Education
Humans
Lung Diseases
National Heart, Lung, and Blood Institute (U.S.)
Protein Folding
Proteostasis Deficiencies
United States
