Medical College of Wisconsin
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Malfolded protein structure and proteostasis in lung diseases. Am J Respir Crit Care Med 2014 Jan 01;189(1):96-103

Date

09/17/2013

Pubmed ID

24033344

Pubmed Central ID

PMC3919126

DOI

10.1164/rccm.201306-1164WS

Scopus ID

2-s2.0-84891868645   33 Citations

Abstract

Recent discoveries indicate that disorders of protein folding and degradation play a particularly important role in the development of lung diseases and their associated complications. The overarching purpose of the National Heart, Lung, and Blood Institute workshop on "Malformed Protein Structure and Proteostasis in Lung Diseases" was to identify mechanistic and clinical research opportunities indicated by these recent discoveries in proteostasis science that will advance our molecular understanding of lung pathobiology and facilitate the development of new diagnostic and therapeutic strategies for the prevention and treatment of lung disease. The workshop's discussion focused on identifying gaps in scientific knowledge with respect to proteostasis and lung disease, discussing new research advances and opportunities in protein folding science, and highlighting novel technologies with potential therapeutic applications for diagnosis and treatment.

Author List

Balch WE, Sznajder JI, Budinger S, Finley D, Laposky AD, Cuervo AM, Benjamin IJ, Barreiro E, Morimoto RI, Postow L, Weissman AM, Gail D, Banks-Schlegel S, Croxton T, Gan W

Author

Ivor J. Benjamin MD Center Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aging
Biomedical Research
Drug Discovery
Education
Humans
Lung Diseases
National Heart, Lung, and Blood Institute (U.S.)
Protein Folding
Proteostasis Deficiencies
United States
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a