Dysbiosis--a consequence of Paneth cell dysfunction. Semin Immunol 2013 Nov 30;25(5):334-41
Date
11/19/2013Pubmed ID
24239045DOI
10.1016/j.smim.2013.09.006Scopus ID
2-s2.0-84888858078 (requires institutional sign-in at Scopus site) 76 CitationsAbstract
The complex community of colonizing microbes inhabiting the mucosal surfaces of mammals is vital to homeostasis and normal physiology in the host. When the composition of this microbiota is unfavorably altered, termed dysbiosis, the host is rendered more susceptible to a variety of chronic diseases. In the mammalian small intestine, specialized secretory epithelial cells, named Paneth cells, produce a variety of secreted antimicrobial peptides that fundamentally influence the composition of the microbiota. Recent investigations have identified numerous genetic and environmental factors that can disrupt normal Paneth cell function, resulting in compromised antimicrobial peptide secretion and consequent dysbiosis. These findings suggest that Paneth cell dysfunction should be considered a common cause of dysbiosis.
Author List
Salzman NH, Bevins CLAuthor
Nita H. Salzman MD, PhD Director, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsDysbiosis
Humans
Microbiota
Paneth Cells