Factors influencing the long-term success of periurethral collagen therapy in the office. Int Urogynecol J Pelvic Floor Dysfunct 2006 Jun;17(4):346-51
Date
10/18/2005Pubmed ID
16228122DOI
10.1007/s00192-005-0011-8Scopus ID
2-s2.0-33744784274 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
INTRODUCTION: Glutaraldehyde crosslinked bovine collagen has been used for periurethral bulking for the treatment of urodynamic stress incontinence since 1989 with variable success. A retrospective study was undertaken to evaluate the factors involved in the long-term success of glutaraldehyde crosslinked bovine collagen used for periurethral bulking in the office.
METHODS: Patients were followed objectively with stress testing after receiving periurethral collagen injection in the office under local anesthesia. Repeat injections were done as necessary during their follow-up appointments. The "success" group was defined as those women who demonstrated negative stress tests for over 1 year following their first injection.
RESULTS: Nineteen of 184 women (10.3%) demonstrated negative stress tests for over 1 year following only one initial injection of glutaraldehyde crosslinked collagen. Their success lasted a mean of 829 days up to the time of follow-up.
CONCLUSION: Prior anti-incontinence surgery was the one factor analyzed that showed a trend toward this long lasting success. No other factors were predictive of negative stress tests for over 1 year. Prior anti-incontinence surgery seems to represent a factor involved in the long-term success of periurethral bulking in the office with glutaraldehyde crosslinked bovine collagen for the treatment of urodynamic stress incontinence.
Author List
Koduri S, Goldberg RP, Kwon C, Dobrez DG, Sand PKMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Collagen
Female
Follow-Up Studies
Humans
Injections
Middle Aged
Retrospective Studies
Treatment Outcome
Urethra
Urinary Incontinence, Stress