Synthesis of medium ring heterocycles using an intramolecular Heck reaction. Org Lett 2004 Aug 19;6(17):3005-7
Date
08/28/2004Pubmed ID
15330669DOI
10.1021/ol0487884Scopus ID
2-s2.0-4444308033 (requires institutional sign-in at Scopus site) 104 CitationsAbstract
Historically, general convergent syntheses of medium ring heterocycles have been difficult to develop. Herein, we describe the synthesis of five classes of heterocycles: dihydrodibenzo[b,f]azepine, -oxocine, and -thiocine and dibenzo[b,f]azepine and -oxepine using a strategy of alkylation followed by highly selective intramolecular Heck arylation reaction. The hetero-tricyclic compounds were available in only two steps starting from commercially available starting materials.
Author List
Arnold LA, Luo W, Guy RKAuthor
Alexander (Leggy) Arnold PhD Professor in the Chemistry & Biochemistry department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
CatalysisChemistry, Organic
Cyclization
Heterocyclic Compounds
Indicators and Reagents
Molecular Structure
