Nitric oxide, proteasomal function, and iron homeostasis--implications in aging and neurodegenerative diseases. Methods Enzymol 2005;396:526-34
Date
11/18/2005Pubmed ID
16291259DOI
10.1016/S0076-6879(05)96044-8Scopus ID
2-s2.0-27744520419 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants. The role of nitric oxide in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.
Author List
Kotamraju S, Kalivendi S, Shang T, Kalyanaraman BAuthor
Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAnimals
Cattle
Cells, Cultured
Homeostasis
Iron
Neurodegenerative Diseases
Nitric Oxide
Proteasome Endopeptidase Complex
Up-Regulation