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Nitric oxide, proteasomal function, and iron homeostasis--implications in aging and neurodegenerative diseases. Methods Enzymol 2005;396:526-34

Date

11/18/2005

Pubmed ID

16291259

DOI

10.1016/S0076-6879(05)96044-8

Scopus ID

2-s2.0-27744520419 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

In this chapter, oxidant-induced transferrin receptor-mediated iron-signaling and apoptosis are described in endothelial and neuronal cells exposed to oxidants. The role of nitric oxide in the regulation of iron homeostasis and oxidant-induced apoptosis is described. The interrelationship between oxidative stress, iron-signaling, and nitric oxide-dependent proteasomal function provides a rational mechanism that connects both oxidative and nitrative modifications.

Author List

Kotamraju S, Kalivendi S, Shang T, Kalyanaraman B

Author

Balaraman Kalyanaraman PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aging
Animals
Cattle
Cells, Cultured
Homeostasis
Iron
Neurodegenerative Diseases
Nitric Oxide
Proteasome Endopeptidase Complex
Up-Regulation