Acetylcholine release in the hippocampus: effects of cholinergic and GABAergic compounds in the medial septal area. Neurosci Lett 1994 Jan 31;166(2):199-202
Date
01/31/1994Pubmed ID
8177500DOI
10.1016/0304-3940(94)90485-5Scopus ID
2-s2.0-0027972643 (requires institutional sign-in at Scopus site) 57 CitationsAbstract
The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions of cholinergic and GABAergic drugs, which alter mnemonic processes, on hippocampal acetylcholine (ACh) release. Hippocampal ACh release was assessed using in vivo microdialysis and HPLC-EC. Oxotremorine and scopolamine produced a dose-dependent decrease in hippocampal ACh release. Muscimol decreased hippocampal ACh release at both high and low doses, although not in a dose-dependent manner. The effects of scopolamine and muscimol are consistent with a role of ACh in mnemonic processing.
Author List
Gorman LK, Pang K, Frick KM, Givens B, Olton DSAuthor
Karyn Frick BA,MA,PhD Professor in the Psychology department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AcetylcholineAnimals
Brain
Cerebral Cortex
Chromatography, High Pressure Liquid
Dose-Response Relationship, Drug
Electrochemistry
Female
Hippocampus
Injections
Microdialysis
Muscimol
Oxotremorine
Parasympathomimetics
Rats
Rats, Inbred F344
gamma-Aminobutyric Acid
