Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road. Oncoimmunology 2013 Nov 01;2(11):e26492
Date
02/04/2014Pubmed ID
24490126Pubmed Central ID
PMC3897565DOI
10.4161/onci.26492Scopus ID
2-s2.0-84892406353 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
Effector T cells become rapidly inactivated after antigen exposure due to extracellular as well as intrinsic signals. We have recently demonstrated that the deletion of diacylglycerol kinases, intrinsic inhibitors of T-cell signaling, enhances the activity of adoptively transferred T cells expressing a chimeric antigen receptor (CAR) specific for a tumor-associated antigen.
