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TGF-β: duality of function between tumor prevention and carcinogenesis. J Natl Cancer Inst 2014 Feb;106(2):djt369

Date

02/11/2014

Pubmed ID

24511106

Pubmed Central ID

PMC3952197

DOI

10.1093/jnci/djt369

Scopus ID

2-s2.0-84893867951 (requires institutional sign-in at Scopus site)   426 Citations

Abstract

Several mechanisms underlying tumor progression have remained elusive, particularly in relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial growth, it appears to promote the progression of advanced tumors. Defects in normal TGF-β pathways partially explain this paradox, which can lead to a cascade of downstream events that drive multiple oncogenic pathways, manifesting as several key features of tumorigenesis (uncontrolled proliferation, loss of apoptosis, epithelial-to-mesenchymal transition, sustained angiogenesis, evasion of immune surveillance, and metastasis). Understanding the mechanisms of TGF-β dysregulation will likely reveal novel points of convergence between TGF-β and other pathways that can be specifically targeted for therapy.

Author List

Principe DR, Doll JA, Bauer J, Jung B, Munshi HG, Bartholin L, Pasche B, Lee C, Grippo PJ

Author

Jennifer A. Doll PhD Assistant Professor in the Biomedical Sciences department at University of Wisconsin - Milwaukee




MESH terms used to index this publication - Major topics in bold

Animals
Anticarcinogenic Agents
Apoptosis
Cadherins
Carcinogenesis
Carcinogens
Cell Proliferation
Cell Transformation, Neoplastic
Disease Progression
Humans
Neoplasms
Neovascularization, Pathologic
Receptors, Transforming Growth Factor beta
Signal Transduction
Transforming Growth Factor beta
Up-Regulation