Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Depressive Symptoms and Longitudinal Changes in Cognition: Women's Health Initiative Study of Cognitive Aging. J Geriatr Psychiatry Neurol 2014 Jun;27(2):94-102

Date

03/04/2014

Pubmed ID

24584465

Pubmed Central ID

PMC4433445

DOI

10.1177/0891988714522697

Scopus ID

2-s2.0-84900547025   20 Citations

Abstract

Elevated depressive symptoms (DS) are associated with incident mild cognitive impairment and probable dementia in postmenopausal women. We examined the association of elevated DS with domain-specific cognitive changes and the moderating role of cardiovascular risk factor severity and cardiovascular disease (CVD). A total of 2221 elderly women who participated in the Women's Health Initiative Study of Cognitive Aging were separated into those with (N = 204) and without (N = 2017) elevated DS. The DS and multidomain cognitive outcomes were measured annually for an average follow-up of 5.04 years. Women with elevated DS showed baseline multidomain cognitive deficits but longitudinal declines in global cognition only. Persistent DS was related to greater global cognition, verbal knowledge and fluency, and memory declines. Significant DS-CVD interactions were observed cross-sectionally (but not longitudinally) for figural memory and fine motor speed. Future studies should investigate the role of nonvascular mechanisms linking DS and cognitive decline.

Author List

Goveas JS, Espeland MA, Hogan PE, Tindle HA, Shih RA, Kotchen JM, Robinson JG, Barnes DE, Resnick SM

Author

Joseph S. Goveas MD Professor in the Psychiatry department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aged
Aged, 80 and over
Aging
Cardiovascular Diseases
Cognition
Cognition Disorders
Cognitive Aging
Cognitive Dysfunction
Cross-Sectional Studies
Dementia
Depression
Female
Humans
Myocardial Infarction
Postmenopause
Risk Factors
Severity of Illness Index
Vascular Diseases
Women's Health