Medical College of Wisconsin
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Does chorionic villus sampling compromise fetal umbilical blood flow? Prenat Diagn 1994 Dec;14(12):1107-12

Date

12/01/1994

Pubmed ID

7899278

DOI

10.1002/pd.1970141203

Scopus ID

2-s2.0-0028672937 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

A possible association of limb reduction defects with chorionic villus sampling (CVS) may be related to compromised umbilical blood flow from the trauma of the procedure. We hypothesized that because CVS may disrupt or compromise umbilical blood flow to the fetus, either by vasoconstriction, bradycardia, or emboli, we would detect these changes using Doppler velocimetry. A cohort of 21 consecutive consenting patients undergoing first-trimester elective CVS for prenatal diagnosis were entered into a prospective longitudinal study. Colour flow Doppler velocimetry was performed on fetal umbilical arterial blood flow immediately before and after CVS to measure the pulsatility index, fetal heart rate, per cent flow time, and maximum flow velocity. Measurements were obtained from three consecutive cardiac cycles in three different umbilical segments and averaged. Potentially confounding variables also recorded included gestational age, method of CVS, number of passes, number of aspirations, placental location, tissue sample size, and operator. Umbilical velocimetry values before and after CVS were compared using the paired t-test and showed no statistically significant differences. No differences were found when data were analysed by gestational age, sample size, method, number of aspirations, placental location, or operator. We were unable to detect any significant change in fetal umbilical arterial blood flow velocimetry or heart rate after performing CVS. Umbilical blood flow does not appear to be routinely compromised by CVS.

Author List

Hibbard JU, Loy GL, Hibbard MC

Author

Judith Hibbard Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Bradycardia
Chorionic Villi Sampling
Constriction, Pathologic
Embolism
Female
Fetus
Gestational Age
Humans
Laser-Doppler Flowmetry
Limb Deformities, Congenital
Longitudinal Studies
Pregnancy
Prospective Studies
Umbilical Arteries