The human platelet receptor(s) for quinine/quinidine-dependent antibodies. Blood Cells 1983;9(2):293-301
Date
01/01/1983Pubmed ID
6318869Scopus ID
2-s2.0-0021020881 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Substantial evidence now exists to associate platelet membrane glycoprotein Ib (GP Ib) with a receptor for quinine/quinidine-dependent platelet-specific antibodies. A direct relationship between GP Ib and this receptor activity has been difficult to establish for several reasons, including: the apparent existence of additional receptor activity not directly attributable to the presence of GP Ib; the variable reactivity of different sera observed by some investigators; the instability of receptor activity in semi-purified, soluble form; and differences in methods used by various laboratories to identify and quantitate either quinine/quinidine-dependent antibodies or platelet receptor activity. Moreover, little attention has been paid to the possibility that the Bernard-Soulier syndrome may represent a more heterogeneous collection of functional and molecular platelet abnormalities than hitherto supposed. As more patients are identified and studied, this possibility can also be addressed. A role for factor VIII-related antigen (VIIIR:Ag) in platelet destruction and/or clearance by drug-antibody complexes remains controversial. The observation that VIIIR:Ag is required for platelet activation in vitro (serotonin release, aggregation and increased platelet factor 3 availability) has been made, yet recent evidence indicates that VIIIR:Ag is not required for binding of antibody to platelets in the presence of drug or for complement-mediated lysis of platelets by antibody and drug. Evidence that VIIIR:Ag participates as part of the initial immunogenic complex is intriguing, yet still unconfirmed.(ABSTRACT TRUNCATED AT 250 WORDS)
Author List
Kunicki TJ, Christie DJ, Aster RHMESH terms used to index this publication - Major topics in bold
AntibodiesAntigens
Blood Platelets
Cell Membrane
Factor VIII
Glycoproteins
Humans
Immune Complex Diseases
Membrane Proteins
Platelet Glycoprotein GPIb-IX Complex
Platelet Membrane Glycoproteins
Quinidine
Quinine
Receptors, Cell Surface
Receptors, Immunologic
Thrombocytopenia
von Willebrand Factor