Platelet satellitism and phagocytosis by neutrophils: association with antiplatelet antibodies and lymphoma. Am J Hematol 1978;4(4):313-23
Date
01/01/1978Pubmed ID
717393DOI
10.1002/ajh.2830040403Scopus ID
2-s2.0-0018072053 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
Satellitism and phagocytosis of platelets by neutrophils in EDTA anticoagulated blood have been considered in vitro phenomena without clinical significance. We observed these in a patient with acute, severe thrombocytopenic purpura who subsequently proved to have malignant lymphoma. Wide oscillations in the platelet count were noted and recurrent, severe gastrointestinal bleeding occurred even when the platelet count was normal. Platelet function was abnormal as shown by decreased platelet adhesion to glass beads, absence of a secondary wave of aggregation in response to ADP and eqinephrine, and no aggregation with collagen. Suspension of control platelets in the patient's plasma induced similar aggregation defects in the control platelets. Combination chemotherapy resulted in regression of lymphadenopathy, but platelet abnormalities and bleeding persisted. Platelet satellitism and phagocytosis by neutrophils seen on peripheral blood films may be associated with true thrombocytopenia, abnormal platelet function and bleeding with an underlying systemic disease.
Author List
White LA Jr, Brubaker LH, Aster RH, Henry PH, Adelstein EHMESH terms used to index this publication - Major topics in bold
AntibodiesBlood Cell Count
Blood Coagulation Tests
Blood Platelets
Female
Humans
Lymphoma
Middle Aged
Neutrophils
Phagocytosis
Platelet Adhesiveness
Platelet Aggregation
