Platelet migration inhibition: a new method for detection of platelet antibodies. Blood 1975 Jun;45(6):741-7
Date
06/01/1975Pubmed ID
1168511Scopus ID
2-s2.0-0016822548 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
A test for platelet antibodies based on the inhibition of migration of platelets from a capillary tube is described. The technique is simple and is capable of detecting antibodies directed against HL-A antigens and the platelet-specific antigen, Pl-A1. Inhibitory activity was detected in sera from two of seven patients with idiopathic thrombocytopenic purpura. The platelet migration inhibition test was as sensitive as platelet lysis and more sensitive than complement fixation, aggregometry, and platelet factor-3 release for detection of the antibodies studied.
Author List
Duquesnoy RJ, Lorentsen DF, Aster RHMESH terms used to index this publication - Major topics in bold
AntibodiesAntibody Specificity
Blood Platelets
Cell Migration Inhibition
Chromium Radioisotopes
Complement Fixation Tests
Female
Histocompatibility Antigens
Humans
Methods
Platelet Aggregation
Purpura, Thrombocytopenic
