Cerebral infarction: effects of dose and magnetization transfer saturation at gadolinium-enhanced MR imaging. Radiology 1994 Feb;190(2):547-52
Date
02/01/1994Pubmed ID
8284414DOI
10.1148/radiology.190.2.8284414Scopus ID
2-s2.0-0028144637 (requires institutional sign-in at Scopus site) 68 CitationsAbstract
PURPOSE: To determine contrast enhancement after cerebral infarction at T1-weighted magnetic resonance (MR) imaging with delayed, gadolinium-enhanced, and magnetization transfer (MT) techniques.
MATERIALS AND METHODS: Ten patients aged 40-81 years with recent infarctions (< 7 days) were prospectively studied at MR imaging. Gadoteridol (0.1 mmol/kg [standard dose] and an additional 0.2 mmol/kg [high dose]) was administered before imaging with and without MT saturation and after a 15-minute delay. Two neuroradiologists ranked enhancement conspicuity.
RESULTS: interobserver concordance was excellent (kappa = .86). Pairwise comparisons revealed high-dose MT images were ranked highest, followed by high-dose delayed non-MT images (P < .01). Standard-dose MT images and initial high-dose non-MT images were ranked intermediately but were not distinguishable from each other (P > .05). Initial and delayed standard-dose MT images were ranked lowest (P < .01) and were not distinguishable from each other.
CONCLUSION: MT saturation and high-dose gadoteridol individually and synergistically improve the depiction of contrast enhancement.
Author List
Mathews VP, King JC, Elster AD, Hamilton CAAuthor
Vincent Mathews MD Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Cerebral Infarction
Contrast Media
Female
Gadolinium
Heterocyclic Compounds
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Organometallic Compounds
