A case of oxaliplatin-induced immune-mediated thrombocytopenia. Blood Res 2014 Mar;49(1):61-4
Date
04/12/2014Pubmed ID
24724069Pubmed Central ID
PMC3974961DOI
10.5045/br.2014.49.1.61Scopus ID
2-s2.0-84896941687 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
Oxaliplatin is a platinum compound used in patients with gastrointestinal malignancies. It is known to evoke a drug-induced immune-mediated thrombocytopenia, which has not been reported in Korea. We describe a 53-year-old man who developed oxaliplatin-induced immune-mediated thrombocytopenia during chemotherapy for colon cancer. Oxaliplatin-dependent IgG platelet antibodies were detected in his serum on flow cytometry. He was treated with immunoglobulin and corticosteroids without any complications. Physicians should consider oxaliplatin-induced immune-mediated thrombocytopenia, when a sudden, isolated thrombocytopenia develops during chemotherapy with oxaliplatin.
