Faculty Collaboration Database

Recovery of vocal fold immobility following isolated patent ductus arteriosus ligation. Int J Pediatr Otorhinolaryngol 2014 Aug;78(8):1316-9

Date

06/03/2014

Pubmed ID

24882459

DOI

10.1016/j.ijporl.2014.05.019

Scopus ID

2-s2.0-84904054106 (requires institutional sign-in at Scopus site)   37 Citations

Abstract

OBJECTIVE: Identify laryngoscopic and functional outcomes of infants with vocal fold immobility (VFI) following patent ductus arteriosus (PDA) ligation and identify predictors of recovery.

METHODS: Retrospective review of patients with VFI following PDA ligation from 2001 to 2012 at a single institution. Inclusion criteria were: (1) PDA ligation as only cardiac surgical procedure; (2) left VFI documented by laryngoscopy; (3) minimum follow up 120 days, with at least 2 laryngoscopies performed. Resolution of VFI was determined at follow-up laryngoscopy. Univariate logistic regression models were used to identify variables associated with VFI recovery.

RESULTS: 66 subjects were included with median follow up of 3.0 (± 2.1) years. The mean gestational age was 24.5 ± 1.4 weeks, mean birth weight 673 ± 167 g, and mean age at procedure was 18.6 ± 14.3 days. Patients presented with respiratory symptoms (39%), dysphonia (78%) and dysphagia (55%). Resolution of VFI was observed in 2/66 (3%) patients. Recovery was documented at 20 days and 11 months respectively. Respiratory symptoms, dysphagia, and dysphonia persisted at last follow up in 11%, 47%, and 20% of patients.

CONCLUSIONS: VFI associated with ligation of the ductus arteriosus has a low rate of recovery. Clinical symptoms frequently persist, and as such regular follow-up by otolaryngologists to mitigate morbidity is indicated.

Author List

Nichols BG, Jabbour J, Hehir DA, Ghanayem NS, Beste D, Martin T, Woods R, Robey T

Author

Thomas C. Robey MD Professor in the Otolaryngology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Child, Preschool
Deglutition Disorders
Ductus Arteriosus, Patent
Dysphonia
Follow-Up Studies
Humans
Iatrogenic Disease
Infant
Infant, Newborn
Intraoperative Complications
Laryngoscopy
Ligation
Recovery of Function
Recurrent Laryngeal Nerve Injuries
Respiratory Sounds
Retrospective Studies
Vocal Cord Paralysis
Work of Breathing