Task-modulation of functional synchrony between spontaneous low-frequency oscillations in the human brain detected by fMRI. Magn Reson Med 2006 Jul;56(1):41-50
Date
06/13/2006Pubmed ID
16767759DOI
10.1002/mrm.20932Scopus ID
2-s2.0-33745699934 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Recent developments in functional MRI (fMRI) technology with high spatial and temporal resolution have made it possible to noninvasively detect spontaneous low-frequency oscillations (SLOs) and quantify their functional synchrony in the human brain. In the present fMRI study the dynamic characteristics of the functional synchrony between SLOs were quantitatively determined by the phase shift index (PSI). With the use of an fMRI-guided voxel-selection method, the SLOs and their functional synchrony were found to be modulated by different memory tasks. The results demonstrate that SLOs in episodic memory-related circuitry have significantly higher synchrony during the performance of declarative memory-encoding activities compared to nondeclarative memory-encoding activities. It is suggested that the dynamic property of SLOs and the quantitative assessment of their functional synchrony could be utilized as a biomarker to noninvasively characterize localized pathophysiological functions in the human brain.
Author List
Xu G, Xu Y, Wu G, Antuono PG, Hammeke TA, Li SJAuthor
Piero G. Antuono MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBrain
Female
Humans
Magnetic Resonance Imaging
Male
Memory
