Prefrontal cortical regulation of fear learning. Trends Neurosci 2014 Aug;37(8):455-64
Date
06/16/2014Pubmed ID
24929864Pubmed Central ID
PMC4119830DOI
10.1016/j.tins.2014.05.004Scopus ID
2-s2.0-84905119090 (requires institutional sign-in at Scopus site) 122 CitationsAbstract
The prefrontal cortex regulates the expression of fear based on previously learned information. Recently, this brain area has emerged as being crucial in the initial formation of fear memories, providing new avenues to study the neurobiology underlying aberrant learning in anxiety disorders. Here we review the circumstances under which the prefrontal cortex is recruited in the formation of memory, highlighting relevant work in laboratory animals and human subjects. We propose that the prefrontal cortex facilitates fear memory through the integration of sensory and emotional signals and through the coordination of memory storage in an amygdala-based network.
Author List
Gilmartin MR, Balderston NL, Helmstetter FJAuthor
Fred Helmstetter PhD Professor in the Psychology / Neuroscience department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
AnimalsFear
Humans
Learning
Prefrontal Cortex
