Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. Curr Opin Chem Biol 2012 Dec;16(5-6):498-506
Date
11/07/2012Pubmed ID
23127359Pubmed Central ID
PMC3518608DOI
10.1016/j.cbpa.2012.10.016Scopus ID
2-s2.0-84872277775 (requires institutional sign-in at Scopus site) 211 CitationsAbstract
Although it is widely accepted that S-nitrosation occurs in vivo, questions remain regarding S-nitrosation as a signaling mechanism. The chemistry of S-nitrosation includes NO oxidation to N(2)O(3) followed by reaction with thiolates, radical recombination of NO and thiyl radicals, and transition metal catalyzed pathways. Once formed, nitrosothiols can be transferred between small molecule or protein thiols through transnitrosation reactions. The pathways that lead to selective S-nitrosation of only a subset of cellular cysteines remain largely unknown. Selectivity may be conferred through colocalization with NOS isoforms, protein-protein interaction driven transnitrosation reactions, regulation of S-nitrosoglutathione levels, or directed denitrosation of protein nitrosothiols.
Author List
Smith BC, Marletta MAAuthor
Brian C. Smith PhD Associate Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCysteine
Humans
Nitric Oxide
Nitric Oxide Synthase
Nitrosation
Protein Interaction Maps
Proteins
S-Nitrosoglutathione
S-Nitrosothiols
Signal Transduction