Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Physical properties of lipid bilayers from EPR spin labeling and their influence on chemical reactions in a membrane environment. Free Radic Biol Med 2009 Mar 15;46(6):707-18

Date

12/30/2008

Pubmed ID

19111611

Pubmed Central ID

PMC2705953

DOI

10.1016/j.freeradbiomed.2008.11.024

Scopus ID

2-s2.0-60749086735   51 Citations

Abstract

The influence of a variety of microenvironmental factors on the inherent reactivity of membrane-located reagents is poorly understood. A goal of this review is to provide detailed profiles of membrane properties, including hydrophobicity, oxygen and nitric oxide solubility and diffusion rates, bilayer penetration of metal ions and metal-ion complexes, and membrane order and fluidity, that can be obtained with EPR spin-labeling methods. These properties can drastically vary with membrane composition, membrane depth, and membrane domain formation, influencing the fate of chemical reactions that occur in a lipid bilayer environment.

Author List

Subczynski WK, Widomska J, Feix JB

Authors

Jimmy B. Feix PhD Professor in the Biophysics department at Medical College of Wisconsin
Witold K. Subczynski PhD Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Chemical Phenomena
Cholesterol
Diffusion
Electron Spin Resonance Spectroscopy
Humans
Hydrophobic and Hydrophilic Interactions
Lipid Bilayers
Membranes
Metals
Nitric Oxide
Oxygen
Reactive Oxygen Species
Solubility