Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Position statement: Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. J Clin Endocrinol Metab 2007 Feb;92(2):405-13

Date

11/09/2006

Pubmed ID

17090633

DOI

10.1210/jc.2006-1864

Scopus ID

2-s2.0-33846991956   822 Citations

Abstract

OBJECTIVE: The objective of the study was to evaluate the current state of clinical assays for total and free testosterone.

PARTICIPANTS: The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion.

EVIDENCE: Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants.

CONSENSUS PROCESS: The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations.

CONCLUSIONS: Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and free testosterone should be established for both genders and children, taking into account the many variables that influence serum testosterone concentration.

Author List

Rosner W, Auchus RJ, Azziz R, Sluss PM, Raff H

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Chemistry, Clinical
Endocrine System Diseases
Endocrinology
Humans
Reference Values
Testosterone
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d