Faculty Collaboration Database

Squamous cell carcinoma arising in a pediatric intra- and paravertebral teratoma. Pediatr Dev Pathol 2006;9(4):328-31

Date

09/02/2006

Pubmed ID

16944983

DOI

10.2350/06-01-0021.1

Scopus ID

2-s2.0-33747893363 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

A 7-year-old boy presented with a 1-year history of back pain radiating to his left scapula and arm, with tenderness to palpation over the area. Laboratory studies were unremarkable. Computed tomographic scan showed a mixed lytic and sclerotic process at the T5-T6 level of the vertebral column in continuity with an adjacent paravertebral soft tissue mass. Nuclear medicine scan demonstrated increased uptake in the T5 vertebral body. Histology revealed invasive squamous cell carcinoma infiltrating mature, gliotic neural tissue, with areas of necrosis and prominent perivascular space involvement. Associated vertebral fragments showed bone destruction, reactive bone formation, and fibrosis. By immunohistochemistry, the carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 5/6, EMA, and MIC-2 (membranous staining). The mature neural tissue was positive for GFAP; immature neural elements were not identified. Based on morphologic, immunohistochemical, and clinical features, this lesion was diagnosed as invasive squamous cell carcinoma arising within an intravertebral and paravertebral teratoma.

Author List

Jarzembowski JA, Ruiz RE

Author

Jason A. Jarzembowski MD, PhD Sr Associate Dean, CEO CSG, Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Biomarkers, Tumor
Carcinoma, Squamous Cell
Child
Humans
Male
Neoplasms, Second Primary
Spinal Neoplasms
Teratoma
Thoracic Vertebrae
Tomography, X-Ray Computed