Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

A Decade of Experience Using mTor Inhibitors in Liver Transplantation. J Transplant 2011;2011:913094

Date

04/05/2011

Pubmed ID

21461386

Pubmed Central ID

PMC3064995

DOI

10.1155/2011/913094

Abstract

Some studies suggest that Sirolimus (SRL) is associated with an increased risk of death in liver transplant recipients compared to treatment with calcineurin inhibitors (CNIs). We compared patients who received SRL or CNI in the first year after liver transplant. Our database included 688 patients who received a liver transplant. The patients were divided into groups. (1) CNI + MPS (mycophenolate sodium) at time of discharge. (2) CNI + MPS at time of discharge; SRL was added within the first 6 months and continued through the first year. (3) CNI + MPS at time of discharge; SRL was added within the first 6 months and discontinued before the first year. (4) SRL as primary immunosuppression. (5) SRL as primary immunosuppression and discontinued before the first year. We used mortality and graft loss as the primary measures of outcome. We also quantified renal function using the change in glomerular filtration rate (GFR), the presence of biopsy proven acute cellular reject (ACR), and steroid-resistant rejection (SRR). There were no significant differences in mortality or graft loss. There was no difference in patient or graft survival. Patients that received SRL as primary immunosuppression had 50% less rejection compared to controls.

Author List

Campsen J, Zimmerman MA, Mandell S, Kaplan M, Kam I

Author

Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin




jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0