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Diagnostic implications of C-reactive protein. Arch Surg 2003 Feb;138(2):220-4

Date

02/13/2003

Pubmed ID

12578424

DOI

10.1001/archsurg.138.2.220

Scopus ID

2-s2.0-0037323278   66 Citations

Abstract

An elevated level of C-reactive protein (CRP), an acute phase protein, is one of many downstream indicators of inflammation. Physiologically, CRP enhances cell-mediated immunity by promoting phagocytosis, accelerating chemotaxis, and activating platelets. The purposes of this article are (1) to review the clinical data implicating serum CRP level as a systemic marker of focal inflammation and (2) to explore serum CRP level as a reflection of the inflammatory component of atherogenesis. Our findings indicate that CRP levels serve as an early marker of the magnitude of inflammation in events as dissimilar as appendicitis and myocardial infarction. The level of circulating CRP correlates with endovascular disease and may serve to identify otherwise asymptomatic patients at sufficient cardiovascular risk to warrant aggressive therapy. Determining whether CRP has a direct pathologic role in the vascular wall itself may have the most clinical relevance.

Author List

Zimmerman MA, Selzman CH, Cothren C, Sorensen AC, Raeburn CD, Harken AH

Author

Michael A. Zimmerman MD, FACS Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Arteriosclerosis
C-Reactive Protein
Humans
Inflammation
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0