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Cerebral localization of impaired phonological retrieval during rhyme judgment. Ann Neurol 2014 Nov;76(5):738-46

Date

08/29/2014

Pubmed ID

25164766

Pubmed Central ID

PMC4214892

DOI

10.1002/ana.24266

Scopus ID

2-s2.0-84912085803   43 Citations

Abstract

OBJECTIVE: Computation of a prearticulatory phonological representation (phonological access, or phonological retrieval) is an essential process in speech production whose neural localization is not clear. This study combined a specific behavioral measure of phonological access and multivariate voxel-based lesion-symptom mapping (VLSM) in a series of left hemisphere stroke patients to identify brain regions critical for this process.

METHODS: Phonological access was assessed in 40 chronic ischemic stroke patients using a silent rhyming task to avoid confounds with motor planning and articulation deficits. Additional covariates were incorporated in the VLSM analysis to control for orthographic and working memory demands of the rhyming task, and for age, education, and total lesion volume. The resulting t statistic maps were thresholded at voxelwise p < 0.001 and cluster-corrected at a familywise error of p < 0.05.

RESULTS: Phonological access impairment was correlated with damage to a focal region of cortex and white matter caudal to the posterior sylvian fissure, which included the posterior supramarginal gyrus and adjacent anterior angular gyrus, planum temporale, and posterior superior temporal gyrus. No correlation was observed with Broca's area, insula, or sensorimotor cortex. An additional VLSM showed no correlation between damage in this posterior perisylvian region and spoken word comprehension.

INTERPRETATION: This is the first demonstration of a specific lesion correlate for phonological access impairment. Although this posterior perisylvian region overlaps with some versions of the classical Wernicke area, the present results demonstrate its involvement in prearticulatory phonological production rather than speech perception or lexical-semantic processes.

Author List

Pillay SB, Stengel BC, Humphries C, Book DS, Binder JR

Authors

Jeffrey R. Binder MD Professor in the Neurology department at Medical College of Wisconsin
Diane S. Book MD Associate Professor in the Neurology department at Medical College of Wisconsin
Sara B. Pillay PhD Assistant Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Auditory Perception
Brain
Brain Mapping
Female
Functional Laterality
Humans
Judgment
Male
Memory
Middle Aged
Psychomotor Performance
Speech
Speech Perception
Stroke