Functional genomics and its implications for molecular medicine. Pediatr Clin North Am 2006 Oct;53(5):807-16, vii
Date
10/10/2006Pubmed ID
17027611DOI
10.1016/j.pcl.2006.08.007Scopus ID
2-s2.0-33749253924 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Technological development in genetics and genomics provides unprecedented possibilities to identify the underlying molecular basic of many common diseases. With the availability of the human genome sequence and growing information on the most frequent DNA variations combined with the molecular analysis on the RNA expression and protein level, diseases might be characterized in the future at the molecular level. Describing gene function anf the specific role of DNA, RNA, and proteins in the disease process provides novel diagnosis tools and treatment. Ultimately how the unique genetic signature of an individual influences the risk and prognosis of disease will be the basis for individualized medicine in the years to come.
Author List
Broeckel U, Maresso K, Kugathasan SAuthor
Ulrich Broeckel MD Chief, Center Associate Director, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
DNA Mutational AnalysisGenetic Markers
Genetic Techniques
Genetics, Medical
Genome, Human
Genomics
Human Genome Project
Humans
Molecular Biology
RNA