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Vascular tumors of infancy and childhood: beyond capillary hemangioma. Cardiovasc Pathol 2006;15(6):303-17



Pubmed ID




Scopus ID

2-s2.0-33750955834 (requires institutional sign-in at Scopus site)   95 Citations


Vascular tumors of infancy and childhood represent a number of clinicopathologically distinct entities for which precise histopathological diagnosis is often essential in determining effective therapeutic approach. Unfortunately, pathologists and clinicians alike have traditionally tended to lump these tumors, in addition to small vessel vascular malformations, under overly generic terms like capillary hemangioma that do little, if anything, to guide proper clinical management. In the last decade this nosologic oversimplification has begun to wane as important new diagnostic tools and better understanding of etiology have evolved, facilitated by international recognition of the need for a multidisciplinary approach in dealing with these perplexing and often clinically devastating lesions. This article provides a brief historical perspective on this progress, and then focuses on the current clinical, histological, and immunophenotypical features that distinguish the major types of vascular tumors of infancy and childhood, also reviewing new evidence regarding their mechanisms of pathogenesis.

Author List

North PE, Waner M, Buckmiller L, James CA, Mihm MC Jr


Paula E. North MD, PhD Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blood Vessels
Child, Preschool
Hemangioma, Capillary
Infant, Newborn
Sarcoma, Kaposi
Skin Neoplasms