Vascular tumors of infancy and childhood: beyond capillary hemangioma. Cardiovasc Pathol 2006;15(6):303-17
Date
11/23/2006Pubmed ID
17113009DOI
10.1016/j.carpath.2006.03.001Scopus ID
2-s2.0-33750955834 (requires institutional sign-in at Scopus site) 95 CitationsAbstract
Vascular tumors of infancy and childhood represent a number of clinicopathologically distinct entities for which precise histopathological diagnosis is often essential in determining effective therapeutic approach. Unfortunately, pathologists and clinicians alike have traditionally tended to lump these tumors, in addition to small vessel vascular malformations, under overly generic terms like capillary hemangioma that do little, if anything, to guide proper clinical management. In the last decade this nosologic oversimplification has begun to wane as important new diagnostic tools and better understanding of etiology have evolved, facilitated by international recognition of the need for a multidisciplinary approach in dealing with these perplexing and often clinically devastating lesions. This article provides a brief historical perspective on this progress, and then focuses on the current clinical, histological, and immunophenotypical features that distinguish the major types of vascular tumors of infancy and childhood, also reviewing new evidence regarding their mechanisms of pathogenesis.
Author List
North PE, Waner M, Buckmiller L, James CA, Mihm MC JrAuthor
Paula E. North MD, PhD Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Blood VesselsChild
Child, Preschool
Hemangioendothelioma
Hemangioma
Hemangioma, Capillary
Humans
Infant
Infant, Newborn
Sarcoma, Kaposi
Skin Neoplasms
