Human heart conjugate cooling simulation: unsteady thermo-fluid-stress analysis. Int J Numer Method Biomed Eng 2014 Nov;30(11):1372-86
Date
07/22/2014Pubmed ID
25045006Pubmed Central ID
PMC4351112DOI
10.1002/cnm.2662Scopus ID
2-s2.0-84911807585 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
The main objective of this work was to demonstrate computationally that realistic human hearts can be cooled much faster by performing conjugate heat transfer consisting of pumping a cold liquid through the cardiac chambers and major veins while keeping the heart submerged in cold gelatin filling a cooling container. The human heart geometry used for simulations was obtained from three-dimensional, high resolution CT-angio scans. Two fluid flow domains for the right (pulmonic) and left (systemic) heart circulations, and two solid domains for the heart tissue and gelatin solution were defined for multi-domain numerical simulation. Detailed unsteady temperature fields within the heart tissue were calculated during the conjugate cooling process. A linear thermoelasticity analysis was performed to assess the stresses applied on the heart due to the coolant fluid shear and normal forces and to examine the thermal stress caused by temperature variation inside the heart. It was demonstrated that a conjugate cooling effort with coolant temperature at +4°C is capable of reducing the average heart temperature from +37°C to +8°C in 25 minutes for cases in which the coolant was steadily pumped only through major heart inlet veins and cavities.
Author List
Abdoli A, Dulikravich GS, Bajaj C, Stowe DF, Jahania MSAuthor
David F. Stowe MD, PhD Professor in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Computer SimulationGelatin
Heart
Humans
Organ Preservation
Software
Stress, Physiological
Temperature
Time Factors