Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta Pharmacol Sin 2008 May;29(5):564-72
Date
04/24/2008Pubmed ID
18430364DOI
10.1111/j.1745-7254.2008.00788.xScopus ID
2-s2.0-42649096690 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
AIM: This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats.
METHODS: The renal blood flow responses to renal nerve stimulation, noradrenaline, phenylephrine, and methoxamine were measured in the absence and presence of nitrendipine, 5-methylurapidil, chloroethylclonidine and BMY 7378.
RESULTS: The renal vasoconstrictor responses were markedly attenuated by nitrendipine and 5- methylurapidil in the diabetic rats (all P< 0.05). In the non-diabetic rats, these responses were markedly attenuated by nitrendipine, 5-methylurapidil, and BMY 7378 (all P< 0.05). In both experimental groups, chloroethylclonidine markedly accentuated the renal vasoconstrictions caused by all the adrenergic stimuli (all P< 0.05).
CONCLUSION: These observations indicate that alpha 1A-adrenoceptor subtypes play a major role in mediating adrenergically-induced renal vasoconstriction in the diabetic 2K1C Goldblatt hypertensive rats. In the non-diabetic 2K1C Goldblatt hypertensive rats, contributions of alpha 1A and alpha 1D-adrenoceptor subtypes were proposed. Apart from post-synaptic alpha 1-adrenoceptors, both in the diabetic and non-diabetic 2K1C Goldblatt hypertensive rats, the potential involvement of presynaptic alpha 1- adrenoceptors is also suggested.
Author List
Armenia A, Sattar MA, Abdullah NA, Khan MA, Johns EJMESH terms used to index this publication - Major topics in bold
Adrenergic alpha-1 Receptor AgonistsAdrenergic alpha-1 Receptor Antagonists
Animals
Clonidine
Diabetes Mellitus, Experimental
Dose-Response Relationship, Drug
Electric Stimulation
Hypertension, Renovascular
Kidney
Male
Methoxamine
Nitrendipine
Norepinephrine
Phenylephrine
Piperazines
Rats
Rats, Sprague-Dawley
Vasoconstriction
