Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise. Ann Biomed Eng 2007 Jun;35(6):956-69
Date
03/24/2007Pubmed ID
17380394Pubmed Central ID
PMC4124918DOI
10.1007/s10439-007-9271-4Scopus ID
2-s2.0-34249685448 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
The energy demand imposed by physical exercise on the components of the oxygen transport and utilization system requires a close link between cellular and external respiration in order to maintain ATP homeostasis. Invasive and non-invasive experimental approaches have been used to elucidate mechanisms regulating the balance between oxygen supply and consumption during exercise. Such approaches suggest that the mechanism controlling the various subsystems coupling internal to external respiration are part of a highly redundant and hierarchical multi-scale system. In this work, we present a "systems biology" framework that integrates experimental and theoretical approaches able to provide simultaneously reliable information on the oxygen transport and utilization processes occurring at the various steps in the pathway of oxygen from air to mitochondria, particularly at the onset of exercise. This multi-disciplinary framework provides insights into the relationship between cellular oxygen consumption derived from measurements of muscle oxygenation during exercise and pulmonary oxygen uptake by indirect calorimetry. With a validated model, muscle oxygen dynamic responses is simulated and quantitatively related to cellular metabolism under a variety of conditions.
Author List
Lai N, Camesasca M, Saidel GM, Dash RK, Cabrera MEAuthor
Ranjan K. Dash PhD Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsComputer Simulation
Energy Metabolism
Exercise
Humans
Models, Biological
Muscle Fibers, Skeletal
Oxygen
Oxygen Consumption
Physical Exertion
Pulmonary Gas Exchange