Coenzyme Q10 and immunity: A case report and new implications for treatment of recurrent infections in metabolic diseases. Clin Immunol 2014 Dec;155(2):209-12
Date
09/30/2014Pubmed ID
25264263DOI
10.1016/j.clim.2014.09.010Scopus ID
2-s2.0-84910062085 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Coenzyme Q10 (CoQ10) deficiency can manifest diversely, from isolated myopathy to multisystem involvement. Immune dysregulation has not been reported as a feature of the disease. We report a four-year old girl with failure to thrive, recurrent infections, developmental delay with hypotonia, and CoQ10 deficiency with impaired immune function, which improved after CoQ10 and immunoglobulin replacement therapy. Immune dysfunction in CoQ10 deficiency should be considered and treated appropriately.
Author List
Farough S, Karaa A, Walker MA, Slate N, Dasu T, Verbsky J, Fusunyan R, Canapari C, Kinane TB, Van Cleave J, Sweetser DA, Sims KB, Walter JEAuthor
James Verbsky MD, PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AtaxiaChild, Preschool
Enzyme Replacement Therapy
Female
Humans
Immunity
Immunoglobulin G
Lymphocyte Subsets
Mitochondrial Diseases
Muscle Weakness
Treatment Outcome
Ubiquinone