Characterization of a novel DQB1 allele associated with HLA-DQw3: implications for oligotyping. Hum Immunol 1992 Mar;33(3):224-7
Date
03/01/1992Pubmed ID
1618660DOI
10.1016/0198-8859(92)90075-xScopus ID
2-s2.0-0026647778 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
During HLA-DQ oligotyping, the presence of a novel HLA-DQB1 allele was suggested by a pattern of probe hybridization that was inconsistent with the presence of any possible combination of two known alleles. The nucleotide sequence of the second exon of the HLA-DQB1 gene was determined, revealing a novel HLA-DQB1 sequence differing from the DQB1*0301 allele by a single nucleotide substitution at codon 57. All published HLA-DQ oligotyping systems could assign inaccurate oligotypes when this allele is present. An additional amplification primer was utilized to achieve discrimination of all possible combinations of known HLA-DQB1 alleles.
Author List
Fenske TS, Baxter-Lowe LAAuthor
Timothy Fenske MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AllelesBase Sequence
HLA-DQ Antigens
HLA-DQ beta-Chains
Humans
Molecular Sequence Data