Imaging of calcium pyrophosphate deposition disease. Curr Rheumatol Rep 2015 Mar;17(3):20
Date
03/13/2015Pubmed ID
25761927Pubmed Central ID
PMC5471493DOI
10.1007/s11926-015-0496-1Scopus ID
2-s2.0-84924787445 (requires institutional sign-in at Scopus site) 47 CitationsAbstract
Calcium pyrophosphate deposition disease (CPPD) is a common and clinically heterogeneous form of arthritis caused by the deposition of calcium pyrophosphate (CPP) crystals in articular tissues. The diagnosis of CPPD is supported by the presence of radiographic chondrocalcinosis; yet, conventional radiography detects only about 40 % of clinically important CPPD. Here, we critically review the recent literature on imaging in CPPD. New studies inform our use of conventional radiographic screening methodologies for CPPD and provide additional evidence for the utility of diagnostic ultrasound. Recent work also highlights the polyarticular nature of CPPD, its association with tissue damage, and the high prevalence of tendon involvement. While dual energy CT and diffraction-enhanced synchrotron imaging remain research tools, they present potential avenues for improved visualization of CPP deposits. Advances in imaging in CPPD will increase diagnostic accuracy and eventually result in better management of this common form of arthritis.
Author List
Miksanek J, Rosenthal AKAuthor
Ann K. Rosenthal MD Associate Dean, Chief, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ArthrographyChondrocalcinosis
Diagnostic Imaging
Humans
Joints
Ultrasonography
