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Nuclear migration during retinal development. Brain Res 2008 Feb 04;1192:29-36

Date

06/15/2007

Pubmed ID

17560964

Pubmed Central ID

PMC2674389

DOI

10.1016/j.brainres.2007.05.021

Scopus ID

2-s2.0-38849104859   89 Citations

Abstract

In this review we focus on the mechanisms, regulation, and cellular consequences of nuclear migration in the developing retina. In the nervous system, nuclear migration is prominent during both proliferative and post-mitotic phases of development. Interkinetic nuclear migration is the process where the nucleus oscillates from the apical to basal surfaces in proliferative neuroepithelia. Proliferative nuclear movement occurs in step with the cell cycle, with M-phase being confined to the apical surface and G1-, S-, and G2-phases occurring at more basal locations. Later, following cell cycle exit, some neuron precursors migrate by nuclear translocation. In this mode of cellular migration, nuclear movement is the driving force for motility. Following discussion of the key components and important regulators for each of these processes, we present an emerging model where interkinetic nuclear migration functions to distinguish cell fates among retinal neuroepithelia.

Author List

Baye LM, Link BA

Author

Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cell Cycle
Cell Lineage
Cell Movement
Cell Nucleus
Humans
Models, Biological
Neuroepithelial Cells
Neurons
Retina
Stem Cells
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0