Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: a structure-activity study. Bioorg Med Chem 2013 Jul 01;21(13):3702-7
Date
05/16/2013Pubmed ID
23673218Pubmed Central ID
PMC3685872DOI
10.1016/j.bmc.2013.04.027Scopus ID
2-s2.0-84878563527 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
We recently reported the anti-cancer and anti-cytomegalovirus (CMV) activity of artemisinin-derived trioxane diphenylphosphate dimer 838. To probe the relationship between chemical structure and anti-CMV and anti-cancer activities, we now report synthesis and evaluation of a series of eight new dimer phosphate ester analogs of 838. This series of novel molecules was screened against human foreskin fibroblasts (HFFs) infected with CMV and against the human Jurkat T cell acute lymphoblastic leukemia cell line. This SAR study confirms the very high anti-CMV and anti-cancer potencies of dimer diphenyl phosphate ester 838 without its being toxic to normal cells.
Author List
Mott BT, He R, Chen X, Fox JM, Civin CI, Arav-Boger R, Posner GHAuthor
Ravit Boger MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Antineoplastic AgentsAntiviral Agents
Artemisinins
Cytomegalovirus
Cytomegalovirus Infections
Dimerization
Esters
Humans
Jurkat Cells
Leukemia
Phosphates