Faculty Collaboration Database

Possible fractionated regimens for image-guided intensity-modulated radiation therapy of large arteriovenous malformations. Phys Med Biol 2007 Sep 21;52(18):5667-82

Date

09/07/2007

Pubmed ID

17804888

DOI

10.1088/0031-9155/52/18/013

Scopus ID

2-s2.0-35848966561 (requires institutional sign-in at Scopus site)   19 Citations

Abstract

The aim of this study was to estimate a plausible alpha/beta ratio for arteriovenous malformations (AVMs) based on reported clinical data, and to design possible fractionation regimens suitable for image-guided intensity-modulated radiation therapy (IG-IMRT) for large AVMs based on the newly obtained alpha/beta ratio. The commonly used obliteration rate (OR) for AVMs with a three year angiographic follow-up from many institutes was fitted to linear-quadratic (LQ) formalism and the Poisson OR model. The determined parameters were then used to calculate possible fractionation regimens for IG-IMRT based on the concept of a biologically effective dose (BED) and an equivalent uniform dose (EUD). The radiobiological analysis yields a alpha/beta ratio of 2.2 +/- 1.6 Gy for AVMs. Three sets of possible fractionated schemes were designed to achieve equal or better biological effectiveness than the single-fraction treatments while maintaining the same probability of normal brain complications. A plausible alpha/beta ratio was derived for AVMs and possible fractionation regimens that may be suitable for IG-IMRT for large AVM treatment are proposed. The sensitivity of parameters on the calculation was also studied. The information may be useful to design new clinical trials that use IG-IMRT for the treatment of large AVMs.

Author List

Qi XS, Schultz CJ, Li XA

Author

Christopher J. Schultz MD Chair, Professor in the Radiation Oncology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Feasibility Studies
Humans
Intracranial Arteriovenous Malformations
Radiography
Radiosurgery
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Surgery, Computer-Assisted