Allergic reactions to E. coli L-asparaginase do not affect outcome in childhood B-precursor acute lymphoblastic leukemia: a Children's Oncology Group Study. J Pediatr Hematol Oncol 2007 Sep;29(9):627-32
Date
09/07/2007Pubmed ID
17805038DOI
10.1097/MPH.0b013e3181483df1Scopus ID
2-s2.0-34548387897 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
We describe the outcome of children with B-precursor acute lymphoblastic leukemia registered on Pediatric Oncology Group 8602 who switched to Erwinia asparaginase (ASP) due to an allergy to the Escherichia coli product. Between February 1986 and January 1991, children in complete remission after induction that included intramuscular E. coli ASP (6000 U/m2x6) were randomized for consolidation. One regimen included intensive weekly intramuscular E. coli ASP (25,000 U/m2/wkx24). In case of an allergic reaction to E. coli ASP, Erwinia ASP was substituted at the same dose and schedule. Of the 540 eligible patients, 408 switched to Erwinia ASP due to an allergic reaction. Allergic reactions were significantly associated with younger age, white race, and standard-risk acute lymphoblastic leukemia. Multivariate Cox analysis adjusting for these factors demonstrated no correlation between the switch per se or the timing of the switch and event-free survival.
Author List
Wacker P, Land VJ, Camitta BM, Kurtzberg J, Pullen J, Harris MB, Shuster JJ, Children's Oncology Study GroupMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Asparaginase
Bacterial Proteins
Burkitt Lymphoma
Child
Child, Preschool
Erwinia
Escherichia coli
Humans
Hypersensitivity
Infant
Male
Treatment Outcome