Early insights into the neurobiology of pain in sickle cell disease: A systematic review of the literature. Pediatr Blood Cancer 2015 Sep;62(9):1501-11
Date
05/16/2015Pubmed ID
25976161Pubmed Central ID
PMC4515148DOI
10.1002/pbc.25574Scopus ID
2-s2.0-84938209147 (requires institutional sign-in at Scopus site) 51 CitationsAbstract
Novel insights into the neurobiology of sickle cell disease (SCD) pain have recently been discovered. We systematically reviewed the literature focusing on original research that examined the biology of pain in SCD and/or addressed assessment or treatment of neuropathic pain in SCD. This review of 15 articles that met inclusion criteria provides epidemiological, basic, and clinical data that support central and/or peripheral nervous system abnormalities likely contribute to sickle cell pain. Continued basic and clinical investigation into pain neurobiology is imperative to translate these discoveries into novel ways to assess and treat neuropathic pain and decrease patient suffering.
Author List
Brandow AM, Farley RA, Panepinto JAAuthor
Amanda Brandow DO Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anemia, Sickle CellAnimals
Central Nervous System Sensitization
Clinical Trials as Topic
Cross-Sectional Studies
Databases, Factual
Disease Models, Animal
Forecasting
Humans
Hyperalgesia
Mice
Models, Neurological
Neuralgia
Pain Management
Pain Measurement
Peripheral Nervous System
Risk Factors
Self Report
Surveys and Questionnaires
