Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

H2S in the Vasculature: Controversy of Mechanisms in Physiology, Pathology and Beyond Cardiol Pharmacol Nishijima, Y., and A. M. Beyer. "H2S in the Vasculature: Controversy of Mechanisms in Physiology, Pathology and Beyond." Cardiol Pharmacol 4.135 (2015): 24-26.

Date

05/01/2015

Abstract

Hydrogen sulfide (H2S) is an endogenously gaseous messenger with a number of physiological effects.

Pharmacological and genetic models point toward an important role for this vasodilator gas in the regulation of

vascular tone, cardiac response to ischemia/reperfusion injury, and inflammation among others. Understanding the

complex interaction of H2S with basic cellular signaling and its impact on endothelial and smooth muscle physiology

may provide insights into the early stages of developing vascular inflammation and atherosclerosis or related

vascular pathologies. The underlying mechanism of action is not completely understood. Recent evidence suggests

a key role of H2S in protecting mitochondria against oxidative damage, regulation of ion channels and modulation of

eNOS activity. This review will focus on the key role of H2S in the regulation of vascular function including free radical

production and its physiological role in health and disease.

Author List

Nishijima, Y Beyer, AM

Author

Andreas M. Beyer PhD Associate Professor in the Medicine department at Medical College of Wisconsin


View Online