Tetracycline compounds with non-antimicrobial organ protective properties: possible mechanisms of action. Pharmacol Res 2011 Feb;63(2):102-7
Date
10/19/2010Pubmed ID
20951211Pubmed Central ID
PMC3031662DOI
10.1016/j.phrs.2010.10.004Scopus ID
2-s2.0-79251631666 (requires institutional sign-in at Scopus site) 166 CitationsAbstract
Tetracyclines were developed as a result of the screening of soil samples for antibiotics. The first(t) of these compounds, chlortetracycline, was introduced in 1947. Tetracyclines were found to be highly effective against various pathogens including rickettsiae, as well as both gram-positive and gram-negative bacteria, thus becoming the first class of broad-spectrum antibiotics. Many other interesting properties, unrelated to their antibiotic activity, have been identified for tetracyclines which have led to widely divergent experimental and clinical uses. For example, tetracyclines are also an effective anti-malarial drug. Minocycline, which can readily cross cell membranes, is known to be a potent anti-apoptotic agent. Another tetracycline, doxycycline is known to exert anti-protease activities. Doxycycline can inhibit matrix metalloproteinases which contribute to tissue destruction activities in diseases such as periodontitis. A large body of literature has provided additional evidence for the "beneficial" actions of tetracyclines, including their ability to act as reactive oxygen species scavengers and anti-inflammatory agents. This review provides a summary of tetracycline's multiple mechanisms of action as a means to understand their beneficial effects.
Author List
Griffin MO, Ceballos G, Villarreal FJAuthor
Michael O. Griffin MD, PhD Associate Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsAnti-Inflammatory Agents
Chlortetracycline
Doxycycline
Humans
Matrix Metalloproteinase Inhibitors
Minocycline
Models, Biological
Off-Label Use
Tetracycline
