Faculty Collaboration Database

Proton magnetic resonance spectroscopy of the hippocampus in patients with mild cognitive impairment: a pilot study. J Comput Assist Tomogr 2007;31(5):666-70

Date

09/27/2007

Pubmed ID

17895774

DOI

10.1097/RCT.0b013e318031bc31

Scopus ID

2-s2.0-34748817512 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

OBJECTIVE: To assess the brain metabolites in the hippocampus of patients with mild cognitive impairment (MCI) using proton magnetic resonance spectroscopy at 0.5 T.

METHODS: Absolute concentrations and ratios to creatine of N-acetyl aspartate, myoinositol, glutamate + glutamine, and choline were measured in the right and left hippocampus of 5 MCI patients and 5 control subjects.

RESULTS: In MCI subjects, reduced N-acetyl aspartate was found in the right hippocampus (P = 0.01), and increased myoinositol was found in the left hippocampus (P = 0.02). Myoinositol/N-acetyl aspartate ratios were higher in the right (P = 0.03) and left (P = 0.01) hippocampus of MCI subjects. No significant difference in the concentration of glutamate + glutamine was observed between the control and MCI groups.

CONCLUSIONS: An increase in myoinositol and a decrease in N-acetyl aspartate may be observed in the preclinical stages of dementia. Ratio measurements of these metabolites may serve as a biomarker for MCI.

Author List

Franczak M, Prost RW, Antuono PG, Mark LP, Jones JL, Ulmer JL

Authors

Piero G. Antuono MD Professor in the Neurology department at Medical College of Wisconsin
Malgorzata Franczak MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Analysis of Variance
Aspartic Acid
Brain Chemistry
Case-Control Studies
Cognition Disorders
Hippocampus
Humans
Image Processing, Computer-Assisted
Inositol
Magnetic Resonance Spectroscopy
Neuropsychological Tests
Pilot Projects
Protons