Medical College of Wisconsin
CTSIResearch InformaticsREDCap

Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury. Brain Res 2010 Jun 22;1340:81-5

Date

04/28/2010

Pubmed ID

20420812

DOI

10.1016/j.brainres.2010.04.047

Scopus ID

2-s2.0-77953121482 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.

Author List

Fee DB, Swartz KR, Scheff N, Roberts K, Gabbita P, Scheff S

Authors

Dominic B. Fee MD Vice Chair, Professor in the Neurology department at Medical College of Wisconsin
Karin R. Swartz MD Assistant Dean, Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Dietary Supplements
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Melatonin
Neurons
Neuroprotective Agents
Rats
Rats, Sprague-Dawley
Spinal Cord
Spinal Cord Injuries