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Effect of urokinase on posterior penetrating eye injuries. Can J Ophthalmol 1985 Dec;20(7):251-3



Pubmed ID


Scopus ID

2-s2.0-0022297736 (requires institutional sign-in at Scopus site)   1 Citation


We studied the effect of urokinase on the natural course of posterior penetrating eye injury in an animal model that consistently results in late tractional retinal detachment. A standard penetrating injury was performed on both eyes of 20 rabbits. Each eye received 0.4 mL of heterologous rabbit plasma. Then 10 000 U of urokinase was injected in one randomly chosen eye of each animal; an equal volume of balanced salt solution (BSS) was injected in the other. By 5 to 6 weeks after the surgery 13 (65%) of the 20 urokinase-injected eyes and 15 (75%) of the 20 BSS-injected eyes showed retinal detachment; the proportions are not significantly different. Gross and microscopic study of the enucleated, sectioned eyes failed to reveal any features distinguishing the control and urokinase-treated eyes. Thus, urokinase did not appreciably alter the natural course of development of late tractional retinal detachment after posterior penetrating eye injury.

Author List

Lee S, Peyman GA, Weinberg D


David V. Weinberg MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Eye Injuries
Retinal Detachment
Sodium Chloride
Urokinase-Type Plasminogen Activator
Wounds, Penetrating